International Society for antiviral research
SARS CoV-2 / COVID-19 Older resources
ISAR has adopted the taxonomy and nomenclature recommended by the Coronavirus Study Group (CSG) of the International Committee on Taxonomy of Viruses. The virus is considered a sister to the SARS virus. This group of coronaviruses has been renamed as SARS-CoVs, and the previously known as 2019-nCoV is now named SARS CoV-2.
ISAR has also adopted the disease name indicated by WHO, COVID-19 (for coronavirus disease- 2019).
With the COVID-19 (Coronavirus disease 2019) outbreak progressing so quickly since it in December 2019, the situation has been very dynamic and the information equally fluid. New information has become available by the hour, drastically changing the potential impact of the epidemic or incrementally increasing our understanding of the outbreak and its agent. In such a dynamic scenario, information becomes too quickly outdated or superseded as to attempt to periodically summarize it or cover it all.
This page includes older, now mostly outdated links. For current information, please see this page
THE ISAR HOSTED WEBINAR ON THE SARS CoV-2 COVID-19 OUTBREAK IS AVAILABLE
Primary sources of official information:
AstraZeneca initiates CALAVI clinical trial with Calquence against COVID-19
NIH clinical trial of hydroxychloroquine, a potential therapy for COVID-19, begins
Lack of evidence to support use of darunavir-based treatments for SARS-CoV-2 - J&J
OLDER UNCLASSIFIED PREPRINTS AND PUBLICATIONS
Analysis and projections of transmission dynamics of nCoV in Wuhan
Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China
(Limited) Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019
Long-Term Persistence of IgG Antibodies in SARS-CoV Infected Healthcare Workers
The global spread of 2019-nCoV: a molecular evolutionary analysis
A Locally Transmitted Case of SARS-CoV-2 Infection in Taiwan
The Pathogenicity of 2019 Novel Coronavirus in hACE2 Transgenic Mice
Caution on Kidney Dysfunctions of 2019-nCoV Patients
Severe acute respiratory syndrome disease named "COVID-2019" WHO
A review on possible therapeutic approaches for the 2019-nCOV
Clinical characteristics of 2019 novel coronavirus infection in China
Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury
Evidence and characteristics of human-to-human transmission of 2019-nCoV
Modelling the epidemic trend of the 2019-nCOV outbreak in Hubei Province, China
Risk assessment of novel coronavirus 2019-nCoV outbreaks outside China
Potent neutralization of 2019 novel coronavirus by recombinant ACE2-Ig
MRCA time and epidemic dynamics of the 2019 novel coronavirus
First Case of 2019 Novel Coronavirus in the United States
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany (the main conclusion of this article - transmission from an asymptomatic patient has been rebutted)
A Novel Coronavirus from Patients with Pneumonia in China, 2019
Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam
Therapeutic Drugs Targeting 2019-nCoV Main Protease by High-Throughput Screening
Evolution and variation of 2019-novel coronavirus
Risk of 2019 novel coronavirus importations throughout China prior to the Wuhan quarantine
Origin time and epidemic dynamics of the 2019 novel coronavirus
Transmission dynamics of 2019 novel coronavirus (2019-nCoV)
The 2019-new coronavirus epidemic: evidence for virus evolution
Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China
Pattern of early human-to-human transmission of Wuhan 2019-nCoV
The incubation period of 2019-nCoV infections among travellers from Wuhan, China
A Novel Coronavirus from Patients with Pneumonia in China, 2019
Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov
Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm
Pattern of early human-to-human transmission of Wuhan 2019-nCoV
Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Models_of_Wuhan_Coronavirus_3CLpro_Protease
Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions
A mathematical model for simulating the transmission of Wuhan novel Coronavirus
Older News:
European Medicines Agency provides free scientific advise to developers of vaccines or therapeutics
CDC guidance on "large" (public or private) gatherings
CDC guidance for individuals at higher risk
CDC guidance on how to be best prepared
WHO:Advice on how to minimize exposure and risk
ECDC: Novel coronavirus (SARS-CoV-2) - Discharge criteria for confirmed COVID-19 cases
EPA: list of disinfectants approved to be used against SARS CoV-2
Phase 3 Randomized Clinical Trial or remdesivir in severe patients of 2019-nCoV Acute Respiratory Disease- Recruiting patients
Phase 3 Randomized Clinical Trial or remdesivir in mild/moderate patients of 2019-nCoV Acute Respiratory Disease- Recruiting patients
All 2019-nCoV clinical trials registered and listed in "clinical trials.gov" (most are not yet recruiting)
WHO Clinical management recommendations
WHO Interim case report form (data to be collected)
WHO laboratory detection guidance
WHO training: Critical care in severe acute respiratory infection
WHO training: Methods for detection, prevention, response and control
WHO: All technical guidance documents
CDC information and documents regarding the 2019-nCOV
SARS CoV-2 RNA is often detected in feces
Care for Critically Ill Patients With COVID-19 JAMA insight
From Containment to Mitigation of COVID-19 in the US- JAMA viewpoint
COVID-19 Antiviral and Pharmacotherapy Recommendations- Nebraska Medicine
The Effect of the COVID-19 Pandemic on Clinic Operations -AMA Education hub
Opinions for and against the name selected for the virus
Coronavirus latest: has the outbreak in China peaked? - A commentary in Nature discussing the apparent peak and the possibility of a secondary peak around February 21 as a consequence of the return to work after the New Year Holiday
Autopsy findings appear to differ for the original SARS and COVID-19
The challenges to molecular diagnostics to confirm SARS CoV-2 infection
A commentary on the naming of the virus and the disease Science commentary
Science swift reaction to the outbreak
Breaking News about the outbreak from Nature
Covid-19 — Navigating the Uncharted
Covid-19: surge in cases in Italy and South Korea makes pandemic look more likely - A commentary in BMJ
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China- CHM commentaryFacing Covid-19 in Italy — Ethics, Logistics, and Therapeutics on the Epidemic’s Front Line
The role of nosocomial infection in the COVID-19 outbreak in Northern Italy and the importance of community based care- NEJM Catalyst "Innovations in Care Delivery"
The convalescent sera option for containing COVID-19
Undiagnosed infections with SARS CoV-2 may be highly prevalent, and a major driver of the pandemic
WHO: the total number of cases and fatalities are now larger outside China than in China
NIH Clinical Trial of Investigational Vaccine for COVID-19 Begins
WHO Declares SARS CoV-2-caused COVID 19 a pandemic (March 11)
The Bill & Melinda Gates Foundation Announces the COVID-19 Therapeutics Accelerator
Remdesivir receives Emergency Use Authorization (EUA) from the FDA
NIH clinical trial shows Remdesivir accelerates recovery from advanced COVID-19
Regulators split on antimalarials for COVID-19- A Discussion in The Lancet
Potential benefit of remdesivir therapy in compassionate care use
China has reported no deaths for more than a month and only a trickle of suspected cases (less than 5 suspected cases at any given time) whereas in the Republic of Korea the number of daily cases has shown an uptick but remains below 50.
The number of daily new cases in Denmark has decreased since the lockdown was eased from mid April 14The number of daily new cases in Denmark has decreased since the lockdown was eased from mid April 14
Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19)
CDC Confirms Possible Instance of Community Spread of COVID-19 in U.S.
WHO: No new countries reporting cases in the last 24 h and the vast majority of cases outside China were acquired in Hubei Province, China
WHO: First death outside China (in a patient who had been in China)
CDC information about number of suspected and confirmed cases in the USA- Updated
WHO statement on cases of COVID-19 surpassing 100,000
The Republic of Korea reports only 131 new cases on March 10, and 92% of Italian cases are still in Lombardia, Emilia Romagna, Veneto, Piemonte, Marche, and Toscana with Campania, Lazio and Liguria reporting more than a 100 cases and Friuli, 93.
WHO- almost 110,000 cases of COVID-19, which is now reported in more than 100 countries.
Can China's COVID-19 strategy work elsewhere?
WHO: Comparison between SARS CoV-2 and influenza
WHO: The increase of COVID-19 cases in the Eastern Mediterranean Region is of great concern
WHO increases the global risk level to "VERY HIGH" (10:24am EST February 28)
Detection of low levels of COVID-19 virus in pet dog in Hong Kong- the significance is still unclear
Who press conference February 27
First confirmed COVID-19 case in South America - abc News and Official Brazilian Health Ministry Twitter
WHO Director-General's opening remarks at the media briefing on COVID-19 - 24 February 2020
Joint WHO and ECDC mission in Italy to support COVID-19 control and prevention efforts
NIH clinical trial of remdesivir to treat COVID-19 begins - In Omaha, Nebraska
Several new countries reporting cases
Four new countries reported COVID-19 in the last 24 h according to WHO records
ECDC statement on the rapid increase of COVID-19 cases in Italy
Coronavirus latest: Infections surge outside China- Nature discussion of the latest infection clusters outside China with no known link to China
COVID-19: fighting panic with information (The Lancet Editorial)
Two new countries report cases, and most new cases outside China were acquired locally
WHO - A new country reporting confirmed COVID 2 (Iran), with apparent local spread (CBC Canada News)
The NIH NIAID makes available images of SARS CoV-2
The disease has been named COVID-19 (for coronavirus disease- 2019)
The official proposal for the name and taxonomy of the virus
WHO Novel Coronavirus (2019-nCoV) advice for the public
WHO video providing background information on the outbreak
A primer on the virus and the outbreak (Nature magazine video)
CBS News Interview with Steven Lee Mayers providing background information on the virus and outbreak
Are pangolins infected with the 2019-nCoV?_Nature commentary on yet unpublished research- A link to the preprint presenting the (limited) evidence under "Pre-Prints and Published papers" below.
Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica)-Previously published research concluding that pangolins are infected with coronaviruses
Gilead Sciences has partnered with Chinese health authorities to conduct a randomized Phase III clinical trial of remdesivir against nCoV (links to the clinical trials under "Primary Sources of Information")
DIAGNOSTICS- CDC: Real-Time RT-PCR Panel for Detection 2019-Novel Coronavirus
The experimental antiviral remdesivir has been made available under request for a limited number of patients, and will be tested against 2019-nCoV
Gilead working with China to test Ebola drug as new coronavirus treatment -Reuters
BBC report on the first 2019-nCoV acute respiratory disease death outside China
Coronavirus outbreak: what’s next? _Nature magazine commentary
Mining coronavirus genomes for clues to the outbreak’s origins Science magazine commentary
WHO declares the new coronavirus outbreak a Public Health Emergency of International Concern
First human-to-human transmission in the USA reported
The 2019 nCoV has been grown in culture in Australia and will be made available to other researchers
WHO situation report : First confirmed person-to-person transmission outside China (Jan 26)
WHO increases the global risk level to "VERY HIGH" (10:24am EST February 28)
Detection of low levels of COVID-19 virus in pet dog in Hong Kong- the significance is still unclear
Who press conference February 27
First confirmed COVID-19 case in South America - abc News and Official Brazilian Health Ministry Twitter
WHO Director-General's opening remarks at the media briefing on COVID-19 - 24 February 2020
Joint WHO and ECDC mission in Italy to support COVID-19 control and prevention efforts
NIH clinical trial of remdesivir to treat COVID-19 begins - In Omaha, Nebraska
Several new countries reporting cases
Four new countries reported COVID-19 in the last 24 h according to WHO records
ECDC statement on the rapid increase of COVID-19 cases in Italy
Coronavirus latest: Infections surge outside China- Nature discussion of the latest infection clusters outside China with no known link to China
COVID-19: fighting panic with information (The Lancet Editorial)
Two new countries report cases, and most new cases outside China were acquired locally
WHO - A new country reporting confirmed COVID 2 (Iran), with apparent local spread (CBC Canada News)
The NIH NIAID makes available images of SARS CoV-2
The disease has been named COVID-19 (for coronavirus disease- 2019)
The official proposal for the name and taxonomy of the virus
WHO Novel Coronavirus (2019-nCoV) advice for the public
WHO video providing background information on the outbreak
A primer on the virus and the outbreak (Nature magazine video)
CBS News Interview with Steven Lee Mayers providing background information on the virus and outbreak
Are pangolins infected with the 2019-nCoV?_Nature commentary on yet unpublished research- A link to the preprint presenting the (limited) evidence under "Pre-Prints and Published papers" below.
Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica)-Previously published research concluding that pangolins are infected with coronaviruses
Gilead Sciences has partnered with Chinese health authorities to conduct a randomized Phase III clinical trial of remdesivir against nCoV (links to the clinical trials under "Primary Sources of Information")
DIAGNOSTICS- CDC: Real-Time RT-PCR Panel for Detection 2019-Novel Coronavirus
The experimental antiviral remdesivir has been made available under request for a limited number of patients, and will be tested against 2019-nCoV
Gilead working with China to test Ebola drug as new coronavirus treatment -Reuters
BBC report on the first 2019-nCoV acute respiratory disease death outside China
Coronavirus outbreak: what’s next? _Nature magazine commentary
Mining coronavirus genomes for clues to the outbreak’s origins Science magazine commentary
WHO declares the new coronavirus outbreak a Public Health Emergency of International Concern
First human-to-human transmission in the USA reported
The 2019 nCoV has been grown in culture in Australia and will be made available to other researchers
WHO situation report : First confirmed person-to-person transmission outside China (Jan 26)
Outbreak of novel coronavirus disease 2019 (COVID-19): situation in Italy
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